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1: Nat Genet. 2004 Dec;36(12):1255-7. Epub 2004 Oct 31.Click here to read Links
Erratum in:
Nat Genet. 2005 Jan;37(1):106.

Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.

Hiller M, Huse K, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, Platzer M.

Institute of Computer Science, Friedrich-Schiller-University Jena, Chair for Bioinformatics, Ernst-Abbe-Platz 2, 07743 Jena, Germany.

Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.

PMID: 15516930 [PubMed - indexed for MEDLINE]