Hepatology. 1992 Apr;15(4):722-5.

Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia.

Board P, Nishida T, Gatmaitan Z, Che M, Arias IM.

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Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111.

Abstract

The Dubin-Johnson syndrome is manifested by conjugated hyperbilirubinemia and pigment accumulation in hepatocellular lysosomes. The TR-rat model is a phenotypic model of the Dubin-Johnson syndrome and is characterized by defective ATP-dependent transport of a group of nonbile acid organic anions, including glutathione-S-conjugates and oxidized glutathione, across the bile canaliculus. Similar ATP-dependent transport mechanisms have been described in erythrocytes. Intact erythrocytes and inverted erythrocyte membrane vesicles from Dubin-Johnson patients, TR-rats and appropriate controls were studied with regard to ATP-dependent transport of dinitrophenyl glutathione and oxidized glutathione. No significant differences were observed, indicating that the erythrocyte and canalicular ATP-dependent transporters for these substrates are functionally and potentially genetically distinct.

PMID:: 1551648; [PubMed - indexed for MEDLINE]

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Cited by 4 PubMed Central articles

MOAT4, a novel multispecific organic-anion transporter for glucuronides and mercapturates in mouse L1210 cells and human erythrocytes. [Biochem J. 1996]
MOAT4, a novel multispecific organic-anion transporter for glucuronides and mercapturates in mouse L1210 cells and human erythrocytes.
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ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.
Leier I, Jedlitschky G, Buchholz U, Center M, Cole SP, Deeley RG, Keppler D. Biochem J. 1996 Mar 1; 314 ( Pt 2):433-7.
Organic anions exhibit distinct inhibition patterns on the low-Km and high-Km transport of S-(2,4-dinitrophenyl)glutathione through the human erythrocyte membrane. [Biochem J. 1993]
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Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia.

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