Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S56-8.

Urine leukotriene B4 in familial Mediterranean fever.

Bentancur AG, Naveh N, Lancri J, Selah BA, Livneh A.

Source

Emergency Medicine Department, Sheba Medical Center, Tel Hashomer, Israel.

Abstract

OBJECTIVE:

To determine urinary leukotriene B4 (LTB4) levels and their role in FMF:

METHODS:

Urinary LTB4 levels were studied using a commercial ELISA kit in 12 FMF patients during abdominal attacks, and 20 FMF patients during remission.

RESULTS:

Urinary LTB4 levels in FMF patients during attacks were comparable to those during remission, but higher than normal levels (p = 0.03).

CONCLUSIONS:

These findings suggest a persistent activation of the leukotriene pathway in FMF. Whether elevated LTB4 levels are the cause or the effect of inflammation is yet to be determined.

PMID:: 15515787; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Leukotriene B4

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