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Clin Exp Rheumatol. 1992 Jan-Feb;10(1):13-7.

Efficacy of intravenous immunoglobulin therapy in a case of autoimmune-mediated chronic active hepatitis.

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  • 1Institute of Clinical Medicine 2, University of Pisa, Italy.


In a patient suffering from histologically-documented immuno-mediated chronic active hepatitis, intravenous immunoglobulin (IVIG) treatment was initiated as an obligatory alternative therapy because of femur head aseptic necrosis which had followed long-term therapy with steroids. The first cycle of IVIG was followed by remission of most symptoms, normalization of liver enzymes, disappearance of circulating immunecomplexes (CIC), and a negative lupus band test. Improvement in the patient's condition was demonstrated, in liver histology, by the disappearance of peri-portal mononuclear cells infiltrates, while immunohistochemistry showed the disappearance of the intracellular IgG deposits.

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