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Eur J Cell Biol. 2004 Jul;83(6):257-62.

The GGA proteins: key players in protein sorting at the trans-Golgi network.

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  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.


The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.

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