The GGA proteins: key players in protein sorting a...[Eur J Cell Biol. 2004]

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1: Eur J Cell Biol. 2004 Jul;83(6):257-62.Links

The GGA proteins: key players in protein sorting at the trans-Golgi network.

Ghosh P, Kornfeld S.

Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

The GGA (Golgi-localized, gamma-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.

PMID: 15511083 [PubMed - indexed for MEDLINE]

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[Mol Cell Neurosci. 2005]
Mammalian GGAs act together to sort mannose 6-phosphate receptors.
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ReviewGGA proteins: new players in the sorting game.
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[J Cell Sci. 2001]
Sorting of mannose 6-phosphate receptors mediated by the GGAs.
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ReviewThe structure and function of GGAs, the traffic controllers at the TGN sorting crossroads.
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[Cell Struct Funct. 2003]
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Cited by 13 PubMed Central articles

Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts.
Cardone M, Porto C, Tarallo A, Vicinanza M, Rossi B, Polishchuk E, Donaudy F, Andria G, De Matteis MA, Parenti G. Pathogenetics. 2008 Dec 1; 1(1):6. Epub 2008 Dec 1.

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Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.
Singer-Krüger B, Lasić M, Bürger AM, Hausser A, Pipkorn R, Wang Y. EMBO J. 2008 May 21; 27(10):1423-35. Epub 2008 Apr 17.

[EMBO J. 2008]
Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.
Pérez-Victoria FJ, Mardones GA, Bonifacino JS. Mol Biol Cell. 2008 Jun; 19(6):2350-62. Epub 2008 Mar 26.

[Mol Biol Cell. 2008]
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Cited by 13 PubMed Central articles

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