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EMBO J. 2004 Nov 10;23(22):4365-70. Epub 2004 Oct 28.

Genomic specification and epigenetic regulation of eukaryotic DNA replication origins.

Author information

  • Instituto de Microbiología Bioquímica, CSIC/Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain.

Abstract

Identification of DNA replication origins (ORIs) at a genome-wide level in eukaryotes has proved to be difficult due to the high degree of degeneracy of their sequences. Recent structural and functional approaches, however, have circumvented this limitation and have provided reliable predictions of their genomic distribution in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, and they have also significantly increased the number of characterized ORIs in animals. This article reviews recent evidence on how ORIs are specified and maintained in these systems and on their regulation and sensitivity to epigenetic signals. It also discusses the possible additional involvement of ORIs in processes other than DNA replication.

PMID:
15510221
[PubMed - indexed for MEDLINE]
PMCID:
PMC526466
Free PMC Article
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