J Ethnopharmacol. 2004 Dec;95(2-3):455-7.

Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

Bischoff TA, Kelley CJ, Karchesy Y, Laurantos M, Nguyen-Dinh P, Arefi AG.

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Department of Pharmacy, Massachusetts General Hospital, Boston, MA 02114, USA. Bischoff.Theodore@MGH.Harvard.edu

Abstract

Folklore reports from Afghanistan prior to the wars described the use of aqueous root extracts of Cichorium intybus (L.) as a light-sensitive plant remedy for malaria. Preparative isolation and bioassay against HB3 clone of strain Honduras-1 of Plasmodium falciparum identified the previously known light-sensitive sesquiterpene lactones Lactucin and Lactucopicrin to be antimalarial compounds.

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Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.
J Ethnopharmacol. 2004 Dec ;95(2-3):455-7.

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