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TGFBR1*6A is not associated with prostate cancer in men of European ancestry.

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  • 1Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid, St Louis, M) 63110, USA.


The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case-control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the (*)6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

[PubMed - indexed for MEDLINE]
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