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    Antimicrob Agents Chemother. 2004 Nov;48(11):4430-4.

    Activity of OPT-80, a novel macrocycle, compared with those of eight other agents against selected anaerobic species.

    Credito KL, Appelbaum PC.

    Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.

    Agar dilution MIC was used to compare activities of OPT-80, linezolid, vancomycin, teicoplanin, quinupristin/dalfopristin, amoxicillin/clavulanate, imipenem, clindamycin, and metronidazole against 350 gram-positive and -negative anaerobes. OPT-80 was active against gram-positive strains only, especially Clostridium spp. (85 strains tested, including 21 strains of C. difficile), with MICs ranging between </=0.016 and 0.25 microg/ml.

    PMID: 15504874 [PubMed - indexed for MEDLINE]

    PMCID: 525447

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