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Biotechnol Annu Rev. 2004;10:123-49.

p75 neurotrophin receptor signaling in the nervous system.

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  • 1Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.


The neurotrophin receptor p75(NTR) has long been known as a receptor for neurotrophins that promote survival and differentiation. Consistent with the role of neurotrophins, p75(NTR) is expressed during the developmental stages of the nervous system. However, p75(NTR) is re-expressed in various pathological conditions in the adult. We now know that p75(NTR) has the ability to elicit bi-directional signals, that result in the inhibition as well as the promotion of the neurite outgrowth. p75(NTR) is a key receptor for myelin-derived inhibitory cues that contribute to the lack of regeneration of the central nervous system.

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