Arch Biochem Biophys. 1992 Apr;294(1):168-72.

Quantification of cytochrome P450 reductase gene expression in human tissues.

Shephard EA, Palmer CN, Segall HJ, Phillips IR.

Source

Department of Biochemistry and Molecular Biology, University College London, United Kingdom.

Abstract

We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little inter-individual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.

PMID:: 1550342; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

The cDNA and deduced protein sequence of house fly NADPH-cytochrome P450 reductase. [Insect Biochem Mol Biol. 1993]
The cDNA and deduced protein sequence of house fly NADPH-cytochrome P450 reductase.
Koener JF, Cariño FA, Feyereisen R. Insect Biochem Mol Biol. 1993 Jun; 23(4):439-47.
Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2. [Ann Hum Genet. 1989]
Isolation of a human cytochrome P-450 reductase cDNA clone and localization of the corresponding gene to chromosome 7q11.2.
Shephard EA, Phillips IR, Santisteban I, West LF, Palmer CN, Ashworth A, Povey S. Ann Hum Genet. 1989 Oct; 53(Pt 4):291-301.
Cloning and sequencing of the major rainbow trout constitutive cytochrome P450 (CYP2K1): identification of a new cytochrome P450 gene subfamily and its expression in mature rainbow trout liver and trunk kidney. [Arch Biochem Biophys. 1994]
Cloning and sequencing of the major rainbow trout constitutive cytochrome P450 (CYP2K1): identification of a new cytochrome P450 gene subfamily and its expression in mature rainbow trout liver and trunk kidney.
Buhler DR, Yang YH, Dreher TW, Miranda CL, Wang JL. Arch Biochem Biophys. 1994 Jul; 312(1):45-51.
Establishment of a novel host, high-red yeast that stably expresses hamster NADPH-cytochrome P450 oxidoreductase: usefulness for examination of the function of mammalian cytochrome P450. [Arch Biochem Biophys. 1997]
Establishment of a novel host, high-red yeast that stably expresses hamster NADPH-cytochrome P450 oxidoreductase: usefulness for examination of the function of mammalian cytochrome P450.
Ohgiya S, Goda T, Hoshino T, Kamataki T, Ishizaki K. Arch Biochem Biophys. 1997 Jul 15; 343(2):215-24.
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7. [Mol Pharmacol. 1989]
Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.
Yamano S, Aoyama T, McBride OW, Hardwick JP, Gelboin HV, Gonzalez FJ. Mol Pharmacol. 1989 Jul; 36(1):83-8.

See reviews... See all...

Cited by 5 PubMed Central articles

Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners. [Biochim Biophys Acta. 2010]
Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners.
Jang HH, Jamakhandi AP, Sullivan SZ, Yun CH, Hollenberg PF, Miller GP. Biochim Biophys Acta. 2010 Jun; 1804(6):1285-93. Epub 2010 Feb 10.
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes. [Drug Metab Dispos. 2009]
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.
Gan L, von Moltke LL, Trepanier LA, Harmatz JS, Greenblatt DJ, Court MH. Drug Metab Dispos. 2009 Jan; 37(1):90-6. Epub 2008 Oct 6.
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. [Genome Res. 2002]
Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.
DeSilva U, Elnitski L, Idol JR, Doyle JL, Gan W, Thomas JW, Schwartz S, Dietrich NL, Beckstrom-Sternberg SM, McDowell JC, et al. Genome Res. 2002 Jan; 12(1):3-15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Quantification of cytochrome P450 reductase gene expression in human tissues.
Quantification of cytochrome P450 reductase gene expression in human tissues.
Arch Biochem Biophys. 1992 Apr ;294(1):168-72.

PubMed
Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiw...
Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiwan.
Emerg Infect Dis. 2004 Sep ;10(9):1702-4.

PubMed
MultiHance in cardiac magnetic resonance imaging.
MultiHance in cardiac magnetic resonance imaging.
Eur Radiol. 2004 Jun ;14 Suppl 7:O71-9; discussion O84-5.

PubMed
Religious coping and psychological adjustment to stress: a meta-analysis.
Religious coping and psychological adjustment to stress: a meta-analysis.
J Clin Psychol. 2005 Apr ;61(4):461-80.

PubMed
Symptomatic giant (10-cm) bone island of the tibia.
Symptomatic giant (10-cm) bone island of the tibia.
Skeletal Radiol. 2005 Jun ;34(6):347-50. Epub 2004 Oct 21 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Quantification of cytochrome P450 reductase gene expression in human tissues.

Source

Abstract

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

MeSH Terms

Substances

Secondary Source ID

LinkOut - more resources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information