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1: Infect Immun. 2004 Nov;72(11):6748-52.Click here to read Click here to read Links

Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human plasminogen.

Ge J, Catt DM, Gregory RL.

Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, USA.

Matrix-assisted laser desorption ionization-time of flight mass spectrometry analysis identified enolase as a cell surface component of Streptococcus mutans, which was confirmed by enzyme-linked immunosorbent assay, Western blotting, and transmission electron microscopy. Surface enolase was demonstrated to bind to human plasminogen and salivary mucin MG2. The results suggested a role for enolase in S. mutans attachment, clearance, or breach of the bloodstream barrier.

PMID: 15501816 [PubMed - indexed for MEDLINE]

PMCID: PMC523000