Synthesis of small molecule CDC25 phosphatases inh...[Bioorg Med Chem Lett. 2004]

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1: Bioorg Med Chem Lett. 2004 Dec 6;14(23):5809-12. Links

Synthesis of small molecule CDC25 phosphatases inhibitors.

Contour-Galcéra MO, Lavergne O, Brezak MC, Ducommun B, Prévost G.

Ipsen Research Laboratories, Institut Henri Beaufour, 5, Avenue du Canada, F-91966 Les Ulis Cédex, France. m-odile.galcera.contour@ipsen.com

A targeted library of small molecules has been prepared to optimize the biological activity of BN82002, our initial lead compound, recently described as an original inhibitor of CDC25 phosphatases. Some of these compounds inhibit CDC25 in the micromolar range and therefore reinforce the interest of CDC25 as an anticancer target.

PMID: 15501045 [PubMed - indexed for MEDLINE]

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Synthesis of small molecule CDC25 phosphatases inhibitors.

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