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J Surg Oncol. 2004 Nov 1;88(2):86-99.

High-mobility group protein 1(Y): metastasis-associated or metastasis-inducing?

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  • 1School of Surgical and Reproductive Sciences and Northern Institute for Cancer Research, Faculty of Medical Sciences, University of Newcastle-upon-Tyne, United Kingdom.


Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis.

(c) 2004 Wiley-Liss, Inc.

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