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1: Science. 2004 Oct 22;306(5696):640-3.Click here to read Links
Comment in:
Science. 2008 Nov 21;322(5905):1176-7.

Systems biology and new technologies enable predictive and preventative medicine.

Hood L, Heath JR, Phelps ME, Lin B.

Institute for Systems Biology, Seattle, WA, USA. lhood@systemsbiology.org

Systems approaches to disease are grounded in the idea that disease-perturbed protein and gene regulatory networks differ from their normal counterparts; we have been pursuing the possibility that these differences may be reflected by multiparameter measurements of the blood. Such concepts are transforming current diagnostic and therapeutic approaches to medicine and, together with new technologies, will enable a predictive and preventive medicine that will lead to personalized medicine.

PMID: 15499008 [PubMed - indexed for MEDLINE]