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1: Ann Rheum Dis. 2005 Mar;64(3):347-54. Epub 2004 Oct 21.Click here to read Click here to read Links

Primary Sjögren's syndrome: new clinical and therapeutic concepts.

Ramos-Casals M, Tzioufas AG, Font J.

Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain. mramos@clinic.ub.es

Sicca features are the central clinical manifestations of Sjögren's syndrome (SS), but recent studies have confirmed that primary SS has a systemic expression, including extraglandular manifestations. Patients with a predominantly extraepithelial expression should be managed differently from patients with predominantly periepithelial or sicca limited disease. In coming years treatment will be based on muscarinic agonists for sicca features and immunosuppressive/biological agents for extraglandular features.

PMID: 15498797 [PubMed - indexed for MEDLINE]

PMCID: PMC1755414