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1: Org Lett. 2004 Oct 28;6(22):4089-92.Click here to read Links
Erratum in:
Org Lett. 2006 Aug 3;8(16):3621.

Solid-phase combinatorial synthesis of peptide-biphenyl hybrids as calpain inhibitors.

Montero A, Albericio F, Royo M, Herradón B.

Instituto de Química Orgánica General, C.S.I.C., Juan de la Cierva 3, 28006-Madrid, Spain.

[structure: see text] The combinatorial parallel synthesis of peptide-biphenyl hybrids on solid support using state of the art of peptide synthesis is reported. Key steps were the N to C addition of an amino moiety, hydrolysis of the methyl ester, and the absence of cross-linked compounds when the 2,2'-diamino-1,1'-biphenyl was incorporated. When tested for activity as calpain inhibitors, some of the compounds exhibited IC(50) values in the nanomolar range.

PMID: 15496106 [PubMed - indexed for MEDLINE]