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    Clin Infect Dis. 2004 Nov 1;39 Suppl 5:S248-57.

    Resistance of herpes simplex virus infections to nucleoside analogues in HIV-infected patients.

    Levin MJ, Bacon TH, Leary JJ.

    Source

    Pediatric Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA.

    Abstract

    Antiviral treatment of herpes simplex virus (HSV) infections with nucleoside analogues has been well established for >2 decades, but isolation of drug-resistant HSV from immunocompetent patients has remained infrequent (0.1%-0.7% of isolates) during this period. Even when drug-resistant HSV is isolated from an immunocompetent patient, this virus, with rare exceptions, is cleared normally without adverse clinical outcome. Although drug-resistant HSV is more commonly isolated from immunocompromised patients (4%-7% of isolates) and is more likely to be clinically significant, the prevalence of drug-resistant HSV even among these patients, has been stable over the past 2 decades. Despite this stable prevalence, disease due to drug-resistant HSV remains an important problem for many immunocompromised patients, including those with HIV infection. This article reviews the prevalence, pathogenesis, and implications of drug-resistant HSV infections in HIV-infected patients.

    PMID:
    15494896
    [PubMed - indexed for MEDLINE]
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