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Nucleic Acids Res. 1992 Mar 11;20(5):1087-91.

Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

Author information

  • 1Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine, Strasbourg, France.

Erratum in

  • Nucleic Acids Res 1992 Apr 11;20(7):1841.

Abstract

NF-Y is a CCAAT-specific transcription factor thought to be involved in the regulation of a variety of eukaryotic genes. It shows a striking sequence similarity with the yeast factor HAP2/3. In an attempt to trace back its evolutionary history, we succeeded in isolating NF-Y cDNA clones from a plant and from several species of vertebrates. The patterns of sequence conservation delineate potential functional domains: A central, highly conserved, domain likely responsible for DNA-binding and subunit interaction; more evolutionarily flexible flanking regions, in which variability is clustered, individualizing conserved glutamine or acidic amino-acids putatively involved in protein-protein contacts.

PMID:
1549471
[PubMed - indexed for MEDLINE]
PMCID:
PMC312095
Free PMC Article
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