Amylin receptors: molecular composition and pharma...[Biochem Soc Trans. 2004]

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1: Biochem Soc Trans. 2004 Nov;32(Pt 5):865-7. Links

Amylin receptors: molecular composition and pharmacology.

Hay DL, Christopoulos G, Christopoulos A, Sexton PM.

School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand. dl.hay@auckland.ac.nz

Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY(1(a)), AMY(2(a)) and AMY(3(a)) in accordance with the association of the CT receptor (CT((a))) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.

PMID: 15494035 [PubMed - indexed for MEDLINE]

Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. [Eur J Neurosci. 2001]
Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors. [Mol Pharmacol. 2006]
Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product. [Biochem Biophys Res Commun. 2000]
Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins. [Receptors Channels. 2002]
Receptor pharmacology. [Adv Pharmacol. 2005]
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Amylin receptors: molecular composition and pharmacology.

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