Cytoskeletal proteins talin and vinculin in integr...[Biochem Soc Trans. 2004]

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1: Biochem Soc Trans. 2004 Nov;32(Pt 5):831-6. Links

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Critchley DR.

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

PMID: 15494027 [PubMed - indexed for MEDLINE]

ReviewIntegrin connections to the cytoskeleton through talin and vinculin.
Biochem Soc Trans. 2008 Apr; 36(Pt 2):235-9.

[Biochem Soc Trans. 2008]
ReviewIntegrin-mediated cell adhesion: the cytoskeletal connection.
Biochem Soc Symp. 1999; 65:79-99.

[Biochem Soc Symp. 1999]
A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.
J Biol Chem. 2004 May 21; 279(21):22258-66. Epub 2004 Mar 18.

[J Biol Chem. 2004]
Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans.
Mol Biol Cell. 1996 Aug; 7(8):1181-93.

[Mol Biol Cell. 1996]
The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.
J Biol Chem. 2006 Mar 17; 281(11):7228-36. Epub 2006 Jan 9.

[J Biol Chem. 2006]
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Cited by 11 PubMed Central articles

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling.
Srivastava J, Barreiro G, Groscurth S, Gingras AR, Goult BT, Critchley DR, Kelly MJ, Jacobson MP, Barber DL. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14436-41. Epub 2008 Sep 9.

[Proc Natl Acad Sci U S A. 2008]
Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.
Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. J Cell Biol. 2008 Jun 30; 181(7):1211-22. Epub 2008 Jun 23.

[J Cell Biol. 2008]
Differences in regulation of Drosophila and vertebrate integrin affinity by talin.
Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ. Mol Biol Cell. 2008 Aug; 19(8):3589-98. Epub 2008 May 28.

[Mol Biol Cell. 2008]
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