Cytoskeletal proteins talin and vinculin in integr...[Biochem Soc Trans. 2004]

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1: Biochem Soc Trans. 2004 Nov;32(Pt 5):831-6. Links

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Critchley DR.

Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

PMID: 15494027 [PubMed - indexed for MEDLINE]

Integrin connections to the cytoskeleton through talin and vinculin. [Biochem Soc Trans. 2008]
Integrin-mediated cell adhesion: the cytoskeletal connection. [Biochem Soc Symp. 1999]
A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. [J Biol Chem. 2004]
Talin requires beta-integrin, but not vinculin, for its assembly into focal adhesion-like structures in the nematode Caenorhabditis elegans. [Mol Biol Cell. 1996]
The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. [J Biol Chem. 2006]
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Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

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