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Biochem Soc Trans. 2004 Nov;32(Pt 5):831-6.

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Author information

  • Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, UK. drc@le.ac.uk

Abstract

The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.

PMID:
15494027
[PubMed - indexed for MEDLINE]
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