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Life Sci. 1992;50(13):PL71-4.

Circadian variation in total plasma tryptophan. Antidepressant treatment: drugs and phase advance.

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  • 1Laboratoire de Biochimie, Hôpital Pasteur, Nice, France.


The authors investigated hourly total plasma tryptophan concentrations over a 24 hour period in 3 patients with bipolar depression during 2 types of treatment: a phase advance process and conventional antidepressant therapy. Both treatment modalities increased the 24 hour mean tryptophan levels and the amplitude of circadian tryptophan concentrations. By contrast, in a previous study, moderately decreased tryptophan levels and a blunted amplitude in the circadian rhythm were observed in these same patients in a depressive phase.

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