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J Virol. 1992 Apr;66(4):2510-3.

Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev.

Author information

  • 1Department of Molecular Virology, Kyoto University, Japan.

Abstract

A nonfunctional mutant of human immunodeficiency virus type 1 Rev was created by deleting seven amino acid residues within the nucleolar targeting signal. This mutant Rev remained in the cytoplasm in expressed cells and strongly inhibited the function of Rev by interfering with the nuclear/nucleolar localization of coexpressed Rev. These findings strongly suggest the multimerization of Rev in the cytoplasm before migration to the nucleus/nucleolus, where wild-type Rev functions as a trans-regulator.

PMID:
1548775
[PubMed - indexed for MEDLINE]
PMCID:
PMC289048
Free PMC Article
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