Structurally simplified macrolactone analogues of halichondrin B

Boris M Seletsky; Yuan Wang; Lynn D Hawkins; Monica H Palme; Gregory J Habgood; Lucian V DiPietro; Murray J Towle; Kathleen A Salvato; Bruce F Wels; Kimberley K Aalfs; Yoshito Kishi; Bruce A Littlefield; Melvin J Yu

doi:10.1016/j.bmcl.2004.08.068

Structurally simplified macrolactone analogues of halichondrin B

Bioorg Med Chem Lett. 2004 Nov 15;14(22):5547-50. doi: 10.1016/j.bmcl.2004.08.068.

Authors

Boris M Seletsky¹, Yuan Wang, Lynn D Hawkins, Monica H Palme, Gregory J Habgood, Lucian V DiPietro, Murray J Towle, Kathleen A Salvato, Bruce F Wels, Kimberley K Aalfs, Yoshito Kishi, Bruce A Littlefield, Melvin J Yu

Affiliation

¹ Department of Medicinal Chemistry, Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA.

PMID: 15482921
DOI: 10.1016/j.bmcl.2004.08.068

Abstract

A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.

MeSH terms

Animals
Cell Division / drug effects
Cell Line, Tumor
Ethers, Cyclic / chemical synthesis
Ethers, Cyclic / chemistry*
Ethers, Cyclic / pharmacology*
Humans
Lactones / chemical synthesis
Lactones / chemistry*
Lactones / pharmacology*
Macrolides
Molecular Conformation
Structure-Activity Relationship

Substances

Ethers, Cyclic
Lactones
Macrolides
halichondrin B