Bioorg Med Chem Lett. 2004 Nov 15;14(22):5537-42.

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.

Newhouse B, Allen S, Fauber B, Anderson AS, Eary CT, Hansen JD, Schiro J, Gaudino JJ, Laird E, Chantry D, Eberhardt C, Burgess LE.

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Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, USA.

Abstract

A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.

PMID:: 15482919; [PubMed - indexed for MEDLINE]

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Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists.

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