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Clin Prostate Cancer. 2004 Sep;3(2):122-4.

Second-line chemotherapy for hormone-refractory prostate cancer: has the time come?

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  • 1University of California at San Francisco, Comprehensive Cancer Center, San Francisco, CA 94115, USA.


Prostate-specific antigen testing has not only led to an earlier diagnosis of prostate cancer, but also to an earlier identification of hormone-refractory prostate cancer (HRPC). Many patients identified early with HRPC may receive first-line taxane-based chemotherapy. Patients who progress after first-line chemotherapy are still quite healthy and desire further therapy. No proven treatment options exist for the second-line treatment of HRPC. Finding new agents that are active in the second-line setting and identifying relevant outcome variables and predictive pretreatment variables are crucial in improving survival and quality of life for this patient population.

[PubMed - indexed for MEDLINE]
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