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J Infect Dis. 2004 Nov 1;190(9):1631-41. Epub 2004 Sep 28.

Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study.

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  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. lbo@na.rau.ac.za.

Abstract

Vitamin D receptor (VDR) gene polymorphisms have been implicated in susceptibility to tuberculosis (TB), but reports have been inconsistent. We genotyped the VDR single-nucleotide polymorphisms (SNPs) FokI, BsmI, ApaI, and TaqI in 1139 case patients and control subjects and 382 families from The Gambia, Guinea, and Guinea-Bissau. The transmission-disequilibrium test on family data showed a significant global association of TB with SNP combinations FokI-BsmI-ApaI-TaqI and FokI-ApaI that were driven by the increased transmission to affected offspring of the FokI F and ApaI A alleles in combination. The ApaI A allele was also transmitted to affected offspring significantly more often than expected. Case-control analysis showed no statistically significant association between TB and VDR variants. BsmI, ApaI, and TaqI showed strong linkage disequilibrium. The significance of the family-based associations found between TB and FokI-BsmI-ApaI-TaqI and the FA haplotype supports a role for VDR haplotypes, rather than individual genotypes, in susceptibility to TB.

PMID:
15478069
[PubMed - indexed for MEDLINE]
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