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    Neurology. 2004 Oct 12;63(7):1286-8.

    A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache.

    Rainero I, Gallone S, Valfrè W, Ferrero M, Angilella G, Rivoiro C, Rubino E, De Martino P, Savi L, Ferrone M, Pinessi L.

    Neurology III Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15-10126 Turin, Italy. irainero@molinette.piemonte.it

    Several polymorphisms of the hypocretin/orexin system genes were evaluated in 109 cluster headache patients and 211 controls. The 1246 G>A polymorphism of the gene was significantly different between cases and controls. Homozygosity for the G allele was associated with an increased disease risk (OR: 6.79, 95% CI, 2.25 to 22.99). The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache.

    PMID: 15477554 [PubMed - indexed for MEDLINE]

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