Cytokine. 2004 Nov 7;28(3):109-23.

Overview of interleukin-2 function, production and clinical applications.

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University at Buffalo, State University of New York, Department of Oral Biology and Department of Microbiology, 3435 Main Street, Buffalo, NY 14214, USA. sgaffen@buffalo.edu

Abstract

The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one of the most extensively studied cytokines. Here we present a broad overview of IL-2 history, functional activities, biological sources, regulation and applications to disease treatment. IL-2 exerts a wide spectrum of effects on the immune system, and it plays crucial roles in regulating both immune activation and homeostasis. Both IL-2 and its multipartite receptor are prototypical of the Type I receptor superfamily, and both have been exploited in numerous ways in the clinic. Despite the wealth of information generated about IL-2 from in vitro culture systems, in vivo mouse knockout models, and clinical trials in humans, fascinating new aspects of its functions in the immune system continue to emerge.

PMID:: 15473953; [PubMed - indexed for MEDLINE]

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