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Dev Cell. 2004 Oct;7(4):460-2.

Untangling the web: mitochondrial fission and apoptosis.

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  • 1Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Departments of Pathology and Medicine, Harvard Medical School, Boston, MA 02115, USA.


Mitochondria exist as an interconnected network that is constantly remodeled by balancing membrane fission and fusion events. A new study by Szabadkai et al. in the October 8th issue of Molecular Cell shows that dynamin-related protein 1 (Drp1)-induced scission hinders the ability of mitochondria to transport calcium across the cell and mediate apoptosis.

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