Display Settings:

Format

Send to:

Choose Destination
Am J Hum Genet. 2004 Dec;75(6):1117-23. Epub 2004 Oct 5.

Evidence for sex-specific risk alleles in autism spectrum disorder.

Author information

  • 1Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.

Abstract

We investigated the genetic aspects of the large sex bias in the prevalence of autism spectrum disorder by monitoring changes in linkage when the family set for an affected sibling pair genome scan is subdivided on the basis of the sex of affected children. This produces a significant excess in the total number of linkage peaks (P=1.3 x 10(-8)) and identifies a major male-specific linkage peak at chromosome 17q11 (P<.01). These results suggest that sexual dichotomy is an important factor in the genetics of autism; the same strategy can be used to explore this possibility in other complex disorders that exhibit significant sex biases.

PMID:
15467983
[PubMed - indexed for MEDLINE]
PMCID:
PMC1182147
Free PMC Article

Images from this publication.See all images (1)Free text

Figure  1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk