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Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14925-30. Epub 2004 Oct 4.

The complete genomic sequence of Nocardia farcinica IFM 10152.

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  • 1Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan.


We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

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