Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14925-30. Epub 2004 Oct 4.

The complete genomic sequence of Nocardia farcinica IFM 10152.

Ishikawa J, Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M.

Source

Department of Bioactive Molecules, National Institute of Infectious Diseases, Shinjuku, Tokyo 162-8640, Japan. jun@nih.go.jp

Abstract

We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

PMID:: 15466710; [PubMed - indexed for MEDLINE]
PMCID: PMC522048

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Research Support, Non-U.S. Gov't

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RNA Polymerase II

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