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Am J Psychiatry. 2004 Oct;161(10):1814-21.

High concordance of bipolar I disorder in a nationwide sample of twins.

Author information

  • 1Department of Mental Health and Alcohol Research, National Public Health Institute, 00300 Helsinki 30, Finland. tuula.kieseppa@ktl.fi.

Abstract

OBJECTIVE:

The few studies of bipolar I disorder in twins have consistently emphasized the genetic contribution to disease liability. The authors report what appears to be the first twin study of bipolar I disorder involving a population-based twin sample, in which the diagnoses were made by using structured, personal interviews.

METHOD:

All Finnish same-sex twins (N=19,124) born from 1940 to 1957 were screened for a diagnosis of bipolar I disorder as recorded in the National Hospital Discharge Register between 1969 and 1991 or self-reported in surveys of the Finnish Twin Cohort in 1975, 1981, and 1990. Thirty-eight pairs were thereby identified and invited to participate in the study; the participation rate was 68%. Lifetime diagnoses were made by using the Structured Clinical Interview for DSM-IV. The authors calculated probandwise and pairwise concordances and correlations in liability and applied biometrical model fitting.

RESULTS:

The probandwise concordance rates were 0.43 (95% CI=0.10 to 0.82) for monozygotic twins and 0.06 (95% CI=0.00 to 0.27) for dizygotic twins. The correlations in liability were 0.85 and 0.41, respectively. The model with no familial transmission was rejected. The best-fitting model was the one in which genetic and specific environmental factors explained the variance in liability, with a heritability estimate of 0.93 (95% CI=0.69 to 1.00).

CONCLUSIONS:

The high heritability of bipolar disorder was demonstrated in a nationwide population-based twin sample assessed with structured personal interviews.

PMID:
15465978
[PubMed - indexed for MEDLINE]
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