Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2004 Oct;14(5):582-8.

Amyloid-beta precursor protein processing in neurodegeneration.

Author information

  • 1Laboratory for Neuronal Cell Biology and Gene Transfer, K.U. Leuven and VIB, Department of Human Genetics, Herestraat 49, 3000 Leuven, Belgium.


The amyloid-beta precursor protein is proteolytically cleaved by secretases, resulting in a series of fragments, including the amyloid-beta peptide of Alzheimer's disease. The amyloid precursor protein, when membrane anchored, could operate as a receptor. After cleavage, the soluble ectodomain exerts a trophic function in the subventricular zone. The amyloid-beta peptide itself has a depressant role in synaptic transmission, with both physiological and pathological implications. During the past two years, much time has been invested in determining the molecular pathways that regulate the processing and the signal transduction of the amyloid precursor protein. However, the absence of consistent and informative phenotypes in different loss of function animal models make elucidating the molecular actions of the amyloid-beta precursor protein an ongoing challenge.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk