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Nature. 1992 Mar 12;356(6365):152-4.

Genetic immunization is a simple method for eliciting an immune response.

Author information

  • 1Department of Medicine, University of Texas, Dallas 75235-8573.

Abstract

To produce an immune reaction against a foreign protein usually requires purification of that protein, which is then injected into an animal. The isolation of enough pure protein is time-consuming and sometimes difficult. Here we report that such a response can also be elicited by introducing the gene encoding a protein directly into the skin of mice. This is achieved using a hand-held form of the biolistic system which can propel DNA-coated gold microprojectiles directly into cells in the living animal. Genetic immunization may be time- and labour-saving in producing antibodies and may offer a unique method for vaccination.

PMID:
1545867
[PubMed - indexed for MEDLINE]
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