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    Nephrologie. 2004;25(5):155-61.

    [Physiological effects of C-peptide].

    [Article in French]

    Source

    Unité de néphrologie pédiatrique, Service de pédiatrie multidisciplinaire, AP-HM Timone-Enfants, Marseille. michel.tsimaratos@ap-hm.fr

    Abstract

    Connecting peptide (C-peptide) is a product of proinsulin cleavage. New findings demonstrate, that it may serve to understand the mechanisms involved in the development of long-term complications in type 1 diabetic patients. The present review focuses on: 1. Making a point about C-peptide-induced tubular effects on the basis of clinical and experimental experiments, 2. Precising the molecular mechanisms involved in C-peptide-induced tubular Na,K-ATPase effects.

    PMID:
    15455788
    [PubMed - indexed for MEDLINE]

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