Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma

O A Kaplya; E Yu Sherstoboev; E P Zueva; T G Razina; E N Amosova; S G Krylova

doi:10.1023/b:bebm.0000038156.50390.c2

Effect of baikal skullcap extract administered alone or in combination with cyclophosphamide on natural cytotoxicity system in mice with Lewis lung carcinoma

Bull Exp Biol Med. 2004 May;137(5):471-4. doi: 10.1023/b:bebm.0000038156.50390.c2.

Authors

O A Kaplya¹, E Yu Sherstoboev, E P Zueva, T G Razina, E N Amosova, S G Krylova

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.

PMID: 15455121
DOI: 10.1023/b:bebm.0000038156.50390.c2

Abstract

Baikal skullcap extract was introduced into cytostatic therapy of mice with Lewis lung carcinoma. This extract potentiated the antimetastatic effect of cyclophosphamide in mice with grafted tumors. Combined treatment with cyclophosphamide and extract of Baikal skullcap modulated cytotoxic activity of natural killer cells and peritoneal macrophages during tumor growth.

MeSH terms

Animals
Antineoplastic Combined Chemotherapy Protocols / pharmacology
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Lewis Lung / drug therapy*
Carcinoma, Lewis Lung / immunology
Cyclophosphamide / pharmacology
Cyclophosphamide / therapeutic use*
Cytotoxicity Tests, Immunologic
Killer Cells, Natural / drug effects
Macrophages / drug effects
Mice
Mice, Inbred Strains
Phytotherapy*
Plant Extracts / pharmacology
Plant Extracts / therapeutic use*
Scutellaria baicalensis

Substances

Plant Extracts
Scutellaria baicalensis extract
Cyclophosphamide