Gene Ther. 2004 Oct;11 Suppl 1:S43-50.

Gene therapy for cystic fibrosis: an example for lung gene therapy.

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Department of Gene Therapy, Faculty of Medicine at the National Heart and Lung Institute, Imperial College, London, UK.

Abstract

Gene therapy is currently being evaluated for a wide range of acute and chronic lung diseases. The requirement of gene transfer into the individual cell types of the complex lung structure will very much depend on the target disease. Over the last decade, the gene therapy community has recognized that there is not even one vector that is good for all applications, but that the gene transfer agent has to be carefully chosen. Gene therapy is particularly attractive for diseases that currently do not have satisfactory treatment options and probably easier for monogenic disorders than for complex diseases. Cystic fibrosis (CF) fulfills these criteria and is therefore a good candidate for gene therapy-based treatment. This review will focus on CF as an example for lung gene therapy and discuss the progress made in this field over the last couple of years.

PMID:: 15454956; [PubMed - indexed for MEDLINE]

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