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J Pediatr Hematol Oncol. 2004 Oct;26(10):665-7.

Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma.

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  • 1Department of Psychiatry, Kansas University-Wichita, Wichita, Kansas, USA.

Abstract

The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA). The authors describe a patient who developed a hyperexcitable blink reflex, without symptoms of OMA, prior to his oncologic diagnosis. The authors believe this may represent a distinct paraneoplastic process caused by increased dopaminergic stimulation of the blink reflex and suggest that children manifesting an unexplained hyperexcitable blink reflex should be screened for occult neuroblastoma.

PMID:
15454839
[PubMed - indexed for MEDLINE]
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