Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Genetics. 2004 Sep;168(1):313-24.

Quantitative trait loci affecting life span in replicated populations of Drosophila melanogaster. II. Response to selection.

Author information

  • 1Department of Biological Sciences, Northern Arizona University, Flagstaff 86011, USA.

Abstract

Three selection experiments were used to identify chromosome regions that contain QTL affecting late-life and early-life fitness in Drosophila melanogaster. The selection experiments were initiated by crossing pairs of inbred lines that had been derived from outbred laboratory populations that had different mean life spans. QTL regions were located by association with microsatellite markers that showed significant selection responses. Regions between recombination map positions 54 and 81 on chromosome 2, between 0 and 30 on chromosome 3, and near locations 49 and 81 on chromosome 3 had the strongest support as locations of life-span QTL. There was good general agreement between the life-span QTL regions that were identified by selection and those that were identified in a companion recombination mapping experiment that used the same fly stocks. Many marker loci responded in opposite directions to selection for late- and early-life fitness, indicating negative genetic correlations or trade-offs between those traits. Indirect evidence suggested that some negative genetic correlations were due to antagonistic pleiotropy.

PMID:
15454545
[PubMed - indexed for MEDLINE]
PMCID:
PMC1448088
Free PMC Article

Images from this publication.See all images (1)Free text

F igure  1.—
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk