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J Virol. 2004 Oct;78(20):11313-20.

Coxsackievirus B4-induced cytokine production in pancreatic cells is mediated through toll-like receptor 4.

Author information

  • 1School of Life Sciences, JMS Building, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom. M.Triantafilou@sussex.ac.uk

Abstract

Coxsackievirus B4 (CBV4), a member of the Picornavirus genus, has long been implicated in the development of insulin-dependent diabetes mellitus (IDDM) caused by virus-induced pancreatic cell damage. The progressive destruction of pancreatic beta cells is responsible for the development of IDDM. It has recently been suggested that CBV4 infection can induce the production of proinflammatory cytokines, and these cytokines seem to be involved in the damage to the insulin-producing cells. In this study we investigated whether toll-like receptors (TLRs) are responsible for triggering the proinflammatory cytokine production in human pancreatic cells in response to CBV4. Here we demonstrate that CBV4 triggers cytokine production through a TLR4-dependent pathway. This interaction seems to be independent of virus attachment and cell entry.

PMID:
15452251
[PubMed - indexed for MEDLINE]
PMCID:
PMC521802
Free PMC Article
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