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    Brain Res. 2004 Oct 22;1024(1-2):251-4.

    Differential brain activation in exclusively homosexual and heterosexual men produced by the selective serotonin reuptake inhibitor, fluoxetine.

    Kinnunen LH, Moltz H, Metz J, Cooper M.

    Committee on Human Development, University of Chicago, 5848 S. University Avenue, Chicago, IL 60637, USA. leann_kinnunen@yahoo.com

    A number of studies have shown a relationship between "sexual orientation" and size of various brain nuclei. We hypothesized that neurotransmitter differences might parallel neuroanatomical differences in the hypothalamus. We administered 40 mg of fluoxetine as a challenge to the serotonergic systems of exclusively homosexual and exclusively heterosexual men and measured cerebral metabolic changes with fluorodeoxyglucose positron emission tomography (FDG-PET). The metabolic differences we observed might reflect underlying neurochemical differences between homosexual and heterosexual men.

    PMID: 15451388 [PubMed - indexed for MEDLINE]

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      Fluoxetine (Prozac) is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won't go away and the need to perform certain actions over and over), some eating disorders, and panic attacks (sud...

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