Free Radic Biol Med. 2004 Oct 15;37(8):1097-104.

The role of heme oxygenase-1 promoter polymorphisms in human disease.

Exner M, Minar E, Wagner O, Schillinger M.

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Department of Laboratory Medicine, Vienna General Hospital, Medical School, A 1090 Vienna, Austria.

Abstract

Heme oxygenase (HO) seems to be a novel protective factor with potent anti-inflammatory, anti-oxidant, and anti-proliferative effects. HO-1, the inducible isoform, is expressed in various tissues and is upregulated by multiple stimuli. However, humans differ quantitatively in their ability to mount an HO-1 response, modulated by two potentially functional polymorphisms in the HO-1 gene promoter region. From several studies it seems that the ability of a patient with certain genotypes to respond strongly in terms of upregulating HO-1 may be an important endogenous protective factor. In the present article we systematically review the hitherto published evidence that promoter polymorphisms in the HO-1 gene exert functional importance by influencing the level of HO-1 expression in different organ systems.

PMID:: 15451051; [PubMed - indexed for MEDLINE]

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Cited by 38 PubMed Central articles

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