Trends Biotechnol. 2004 Oct;22(10):491-3.

An array of diverse microbial genomes.

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Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. melinda.pettigrew@yale.edu

Abstract

Methods for comparing gene frequencies across large, epidemiologically defined bacterial collections are limited. A novel microarray technology has been developed called 'library on a slide'. In this technology, hundreds of entire microbial genomes are arrayed, rather than sequences of a single genome or sets of genes. These slides can then be probed for the presence of specific genes allowing researchers to draw inferences regarding important differences between related strains that differ in their pathogenic potential.

PMID:: 15450738; [PubMed - indexed for MEDLINE]

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Review

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DNA, Bacterial

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