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Cleve Clin J Med. 2004 Aug;71(8):609-16.

Lessons from the PROVE-IT trial. Higher dose of potent statin better for high-risk patients.

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  • 1Division of Cardiology, Department of Medicine, University of California, San Francisco 94143, USA.


The Pravastatin or Atorvastatin Evaluation and Infection Therapy trial (PROVE-IT/TIMI-22) showed that in patients with acute coronary syndromes, aggressive lipid-lowering using atorvastatin 80 mg/day provided greater protection against death or major cardiovascular events than did moderate lipid-lowering using pravastatin 40 mg/day. Lowering the low-density lipoprotein cholesterol level to approximately 62 mg/dL with atorvastatin resulted in a 16% reduction in cardiovascular end points.

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