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J Biomed Opt. 2004 Sep-Oct;9(5):928-33.

New fluorescence imaging probe with high spatial resolution for in vivo applications.

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  • 1Université de Franche-Comté, Laboratoire d'Optique P.M. Duffieux, UMR CNRS 6603, Institut des Microtechniques des Microtechniques de Franche-Comte, Faculté des Sciences et des Techniques, Route de Gray, 25030 Besançon Cedex, France.


A new fiberized fluorescence imaging probe is presented. This device can potentially be used for a wide range of biological or medical applications. By exploiting the chromatic aberrations of gradient index lenses, the excitation blue or near-UV excitation light is focused on the sample surface, while the red fluorescence signal is efficiently launched back to collecting fibers. The excitation fiber is single mode at the working wavelength so that a resolution of 5 microm is obtained over a scanning area of several square millimeters. Experimental fluorescence images are presented. They concern either self-fabricated fluorescent microsamples or views of leaves that constitute an example of biological tissues analysis. The probe can also be adapted for spectroscopic investigations.

(c) 2004 Society of Photo-Optical Instrumentation Engineers.

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