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    FEBS Lett. 1992 Feb 24;298(2-3):133-6.

    Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA).

    Hiramatsu K, Asada K, Suzuki E, Okonogi K, Yokota T.

    Source

    Department of Bacteriology, Juntendo University, Tokyo, Japan.

    Abstract

    Molecular cloning and nucleotide sequence analysis were performed for the identification of the regulator genes of methicillin resistance in the genome of a MRSA strain N315. Two open reading frames (orfs) were identified in the 5'-flanking region of the mecA gene. Predicted amino acid sequences of these orfs showed extensive homology to the co-inducer and the repressor protein of the penicillinase (PCase) production in Staphylococcus aureus as well as in Bacillus licheniformis. These orfs are considered to encode putative co-inducer and repressor proteins specific for the regulation of methicillin resistance in MRSA.

    PMID:
    1544435
    [PubMed - indexed for MEDLINE]

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