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Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor.
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
The gene of human angiotensin II type 1 (AT1) receptor was isolated from a lymphocyte genomic library. The coding region of the human AT1 receptor gene was contained in a single exon coding segment of the gene indicating an intronless structure of the coding region. The amino acid sequence of human AT1 receptor deduced from its base sequence has 359 amino acids and showed a high degree of sequence identity to bovine and rat AT1 receptor sequences. Amino acid substitutions specific to the human AT1 receptor were mostly confined to the carboxy terminal half of the molecule. The seven-transmembrane domains are well-conserved in those sequences.
PMID: 1543512 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis.
Valencia JC, Pacheco-Rodriguez G, Carmona AK, Xavier J, Bruneval P, Riemenschneider WK, Ikeda Y, Yu ZX, Ferrans VJ, Moss J.
Am J Respir Cell Mol Biol. 2006 Jul; 35(1):40-7. Epub 2006 Feb 10.
[Am J Respir Cell Mol Biol. 2006]
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Highly sensitive detection of gene expression of an intronless gene: amplification of mRNA, but not genomic DNA by nucleic acid sequence based amplification (NASBA).
Heim A, Grumbach IM, Zeuke S, Top B.
Nucleic Acids Res. 1998 May 1; 26(9):2250-1.
[Nucleic Acids Res. 1998]
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Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture.
Matsubara H, Kanasaki M, Murasawa S, Tsukaguchi Y, Nio Y, Inada M.
J Clin Invest. 1994 Apr; 93(4):1592-601.
[J Clin Invest. 1994]
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