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Science. 1992 Mar 13;255(5050):1430-2.

Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M.

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  • 1Department of Cell Biology, Advanced BioScience Laboratories, Inc., Kensington, MD.

Abstract

Conditioned medium from human T cell leukemia virus type 2 (HTLV-II)-infected T cells supports the growth and long-term culture of cells derived from acquired immunodeficiency syndrome (AIDS)-associated Kaposi's sarcoma lesions (AIDS-KS cells). A protein of 30 kilodaltons was purified from conditioned medium that supports the growth of AIDS-KS cells. The amino-terminal sequence of this protein was identical to the amino-terminal sequence of Oncostatin M, a glycoprotein that inhibits the growth of a variety of cancer cells. Oncostatin M from conditioned medium stimulated a twofold increase in the growth of AIDS-KS cells at a concentration of less than 1 nanogram of the protein per milliliter of medium.

PMID:
1542792
[PubMed - indexed for MEDLINE]
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