Your browser version may not work well with NCBI's Web applications. More information here...
1: Br J Rheumatol. 1992 Mar;31(3):169-74.Click here to read Links

Segregation analysis of collagen genes in two families with joint hypermobility syndrome.

Henney AM, Brotherton DH, Child AH, Humphries SE, Grahame R.

Centre for Genetics of Cardiovascular Disorders, University College and Middlesex School of Medicine, Rayne Institute, London.

We carried out a segregation analysis comparing the inheritance of collagen gene markers and joint hypermobility syndrome in two extended families. Our results exclude the genes encoding type III (COL3A1), type V alpha 2 chain (COL5A2) and type VI alpha 3 chain (COL6A3) unambiguously in both families. The simultaneous exclusion of both the type 1 alpha 1 and alpha 2 chain genes in the same family was not possible: COL1A1, but not COL1A2 was excluded in one and COL1A2, but not COL1A1 was excluded in the second. There was no suggestion of strong linkage to either of these loci. These data do not support the hypothesis that JHS in these families is caused by mutations in these collagen genes.

PMID: 1540784 [PubMed - indexed for MEDLINE]